PHARMACOLOGICAL CORRECTION OF OXIDATIVE AND METABOLIC STATUS WITH CYTOSTATIC DISEASE CAUSED BY THE CHEMOTHERAPY

Mikulyak Nadezhda Ivanovna, Candidate of biological sciences, associate professor, head of sub-department of human physiology, Medical Institute, Penza State University, normphys@mail.ru

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State of oxidative and metabolic status was studied under experimental introduction of chemotherapeutic agents doxorubicin and cyclophosphanum and its correction by mexidol, nooklerin, ethylmethylhydroxypyridine succinate. Shown that the study drugs eliminate the introduction of cytotoxic drugs induced lipid peroxidation, functional disorders of the liver, reduce the severity of cytolytic syndrome, hepatocellular insufficiency, cholestasis, reduced cholesterol forming function and protein forming function. The latter determines the feasibility of using maintenance drugs in adjuvant therapy in the treatment of cancer pathology.

oxidative, metabolic status, lipid peroxidation, cytolysis syndrome, hepatocellular insufficiency, mexidol, nooklerin, ethylmethylhydroxypyridine succinate.